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Based on the reactive species (such as OH, O, OH, HO 2 , O 2 - , NO, NO 2 ) produced when plasma interacts with liquids, the efficacy in eliminating toxic and environmentally persistent substances, as well as organic compounds in polluted water has been extensively confirmed 21,22

The acquired resistance of tumor cells to TKIs is partially reversed by inhibiting IGFBP-1 and the combination of antiangiogenic TKIs and IGFBP-1 inhibitors may be a promising therapeutic strategy for HCC (135)