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Less common side effects of PT-141 Even though PT-141 is generally well-tolerated, it is important to remember that how often and how bad these side effects are can vary from person to person

DOI: 10.1136/gutjnl-2017-313750

doi: 10.3389/fendo.2022.847401 15 ZaissMMJonesRMSchettGPacificiR

However, there are some indirect evidences supporting that inhibition of HDAC by VPA can enable methylated DNA to be more accessible to DNA demethylase, leading to DNA demethylation [135], which suggests that the induction of the methylation of Scn3a promoter by VPA is likely to be affected by the regulation of HDAC

Steensgaard DB, Thomsen JK, Olsen HB, Knudsen LB