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Thioredoxin-interacting protein (TXNIP), a suppressor of glucose uptake known to be active in low-glutamine conditions as a glycolytic sensor, was found to be strongly expressed in the glutamine-deprived setting in activated CD8+ T cells [151]

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As with fish oil, because curcumin has potent anti-inflammatory and antioxidant effects and because virtually all chronic diseases are characterized by these factors, curcumin has been used by clinicians for a wide variety of conditions

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There is every reason to argue that the efficacy observed for compounds 1 and 2 in vivo incorporates a similar role for the host immune response as seen for other schistosomicidal agents