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Afamelanotide received EMA approval in December 2014 and FDA approval on 8 October 2019 , in both cases specifically to increase pain-free light exposure in adults with a history of phototoxic reactions from erythropoietic protoporphyria

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186 the latter will also show keratin decoration in the modified myoepithelia that make up the cell populace, thus enabling distinction when the appropriate immunohistochemical cocktail is applied