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avoidance recommended as a precaution Active malignancy: Pro-angiogenic mechanism warrants caution until more data is available History of hormone-sensitive cancers: Discuss thoroughly with your physician Severe coagulation disorders: Given vascular effects, clinical assessment required Patients on certain anticoagulants: Monitoring required

A low-calorie diet is the standard recommendation for patients with PWS to achieve weight management, and several types of diets have been suggested, i.e., a low-fat low-calorie diet, a modified plant-based food pyramid, and the red, yellow, green diet, which prefers plant foods restricting high-fat and high-energy ones [90, 91]

No draining was necessary and by day ten no belly at all

The Phase 3 TRIUMPH-4 trial (results published December 2025) showed 28.7% body weight loss at 68 weeks the largest reduction seen in any obesity drug trial to date