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"Hair loss is a patient-valued outcome," lead researcher Yong Chen wrote, adding that it can affect "self-esteem, quality of life, and adherence to treatment." For many, the benefits vastly outweigh the drawbacks, but researchers said the findings should help patients understand the potential trade-offs before startingor deciding whether to continuethe highly popular medication.

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Decreases in LCAs and MCAs in E4s may reflect poor mitochondrial FAO capacity or alternatively increased cellular reliance on FAs to support bioenergetics in the cerebrovasculature