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PMC 4437467

You have higher levels of the chemicals homocysteine and methylmalonic acid and reduced DNA synthesis, leading to neurological and psychological symptoms, such as confusion, mood swings, problems walking or talking, and irritability

In the gnomAD database 15 , the rs10305420 T allele is most common in the European (40%) and Middle Eastern (38%) ancestry groups, followed by the Admixed American (28%), South Asian (20%) and East Asian (16%) ancestry groups, and least common in the African (7%) ancestry group

Dietary modification represents the first-line approach and often provides symptom relief

Muller, P