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Early evidence already suggests that such multiplex regimens outperform single-agent therapy where metabolic heterogeneity blunts isolated responses (81, 85) (Table 3) Future work must dissect mechanism-specific dosing ratios, develop quantitative biomarkers of combinatorial efficacy, and deliver large, stratified, randomized trials to confirm both safety and clinical relevance

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[197] explored another approach for utilizing ketosis in PD, investigating how a ketone ester drink might affect exercise endurance in individuals diagnosed with PD

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To date, under unremitting efforts, RA has been altered from a highly disabling disease without effective treatment to a disease that can be well controlled