Given their glucose-lowering effects, GLP-1s have become standard of care for type 2 diabetes, supplanting other medication classes such as sulfonylureas.2 In 2023, GLP-1s represented 63% of diabetes spend, up from 38% in 2020.2 While diabetes GLP-1s will continue to account for a greater portion of spend compared to obesity, costs related to GLP-1s prescribed for obesity are expected to grow at a faster rate over the next 3 years
Kidney Int 88(5):958966 Rossi M, Johnson DW, Morrison M et al (2016) Synbiotics Easing Renal Failure by Improving Gut Microbiology (SYNERGY): a Randomized Trial
Thats because your body readily removes excess folate, as its a water-soluble vitamin ( The tolerable upper limit (UL) of this vitamin, or the highest dose unlikely to cause adverse effects, is 1,000 mcg per day
Akhondzadeh S, Tabatabaee M, Amini H, Ahmadi Abhari SA, Abbasi SH, Behnam B
Comp Biochem Physiol B 1985;81:653-9