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However, control of the mechanism of GSH synthesis in malignant tumors remains poorly understood

And so when patients have multiple sites of injury

7 GST is involved in facilitating tumor resistance and suppressing apoptosis in tumor cells via two mechanisms

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The responsible conclusion is conservative: CJC-1295 has short-term human tolerability data for the DAC form, but long-term safety remains insufficiently characterized, and regulatory agencies have raised meaningful safety and quality-control concerns