Crucially, the obesity paradox is likely heavily confounded by two factors: (1) whether weight loss is intentional, and (2) the use of the BMI metric, which poorly reflects the contribution of body composition towards body weight in older adults [15, 34]
9 According to current guidelines, GLP-1 receptor agonists (GLP-1RA) are the first-line therapy in T2DM, especially in patients with atherosclerotic cardiovascular disease or obesity, and some of them are recommended for obese people without T2DM
A 24 settimane dal cambio di terapia, i pazienti passati a orforglipron hanno sostanzialmente mantenuto il peso perso (variazione media di 0,1 kg nel braccio ex-semaglutide e +2,6 kg in quello ex-tirzepatide), mentre chi passato a placebo ha recuperato oltre 9 kg in entrambi i bracci
I have felt ugly for my entire life, and a prefrontal-cortex belief that the expectations are unreasonable is no match for lizard-brain insecurities
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