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In pentobarbital anaesthetised rats, ipamorelin released GH with a potency and efficacy comparable to GHRP-6 (ED50 = 80+/-42nmol/kg and Emax = 1545+/-250ng GH/ml vs 115+/-36nmol/kg and 1167+/-120ng GH/ml)

An emerging focus of this review is the bonebrain axis, a bidirectional communication pathway that has recently garnered attention for its potential in modulating neurological diseases

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Fast injection creates a sudden bolus of fluid in the subcutaneous tissue, which causes pressure, stinging, and sometimes lump formation