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[PubMed] 205

The importance of this antioxidant pathway is illustrated in Nrf2 knockout mice in which lung neutrophil inflammation and pulmonary emphysema were evident as early as 8 weeks after cigarette smoke exposure, whereas wild-type mice showed no lung changes at 16 weeks

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Situations that typically call for extra caution include: Complex medical histories Pregnancy or breastfeeding Active cancer or history of certain cancers, depending on individual context Significant cardiovascular or clotting risk factors People taking multiple medications that could complicate the picture This is not meant to scare anyone