BCAAs may participate in disease progression from simple steatosis to metabolic dysfunction-associated steatohepatitis (MASH, formerly NASH) through multiple mechanisms, though this pro-disease role is specific to the non-cirrhotic stage in which catabolic impairmentrather than deficiencydrives BCAA accumulation, including promotion of lipogenesis, induction of mitochondrial dysfunction, and activation of inflammatory pathways
4.2 Relationship between baseline GSH levels and cognitive integrity We did not observe a relationship between GSH levels in either region and general cognitive integrity as measured by the MoCA
Faster binding rates indicate higher affinity, while slower release suggests strong chelation
RSS-responsive fluorescence imaging RSS mainly includes cysteine (Cys), homocysteine (Hcy), and glutathione (GSH), which have high reactivity and play irreplaceable roles in physiological and pathological processes
Amgens three drug candidates, namely olpasiran, tarlatamab and AMG133, have shown encouraging results in clinical trials
