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Finally, berberine is strictly contraindicated for pregnant women, as it can cross the placenta and has been linked to kernicterus (a form of brain damage) in newborns

The FDA's Pharmacy Compounding Advisory Committee (PCAC) is scheduled to review TB-500 in July 2026 for possible placement on the 503A Bulks List (Category 1)

The combination of AOD-9604 with hyaluronic acid appears particularly promising, suggesting enhanced benefits through complementary mechanisms

Rotate injection sites systematically to help minimize irritation and support consistent absorption