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Individuals with severe kidney failure, decompensated liver disease, congestive heart failure with fluid overload, non-ketonic hyper-glycemia, or known hypersensitivity to formulation components should not receive glycine.Patients on clozapine should likewise avoid glycine unless supervised closely, as it may blunt clozapines efficacy

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It has been the subject of published research into melanocortin receptor pharmacology, particularly at the MC1R (melanogenesis-associated) and MC4R receptors

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