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10.1016/j.neulet.2007.01.004 132

NLRP3 deficiency ameliorates renal inflammation and fibrosis in diabetic mice

This insight, which implied that a substance could be harmful at a high dose but beneficial or benign at a low one, directly prefigured the biphasic dose-responses central to hormesis and laid the groundwork for modern toxicology

Srivastava S, Basak U, Naghibi M, Vijayakumar V, Parihar R, Patel J, et al

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