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During a three-week treatment period, both Cagrilintide and salmon calcitonin (sCT), another amylin receptor agonist, produced an acute reduction in food intake in WT mice on day 1 by 53% and 42%, respectively, but not in RAMP1/3 KO mice

Insulin concentrations are expressed as a function of both rate and islet number (ng ml 1 (1/200 l ml 1 ) (1/75 islets)) 49

Its unique profile (native gastric peptide, stable without carriers, effective at nanogram doses, modulating multiple interconnected neurotransmitter systems simultaneously, promoting actual neuronal repair rather than just symptomatic relief) distinguishes it from all existing psychiatric medications

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