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In Streptococcus mutans , S-glutathionylation of cysteine residue 41 (C41) in a thioredoxin-like protein (Tlp) was found to be important for interspecies competition [42]

Key trials and reviews include a recent review, a randomized trial, and an MDPI analysis

However, complete symptom resolution often requires several weeks to months of consistent treatment

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Although the absolute risk remains relatively low, studies show a modest but consistent increase in gallstones and cholecystitis among treated patients compared to placebo