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In vitro glutathione peroxidase mimicry of ebselen is linked to its oxidation of critical thiols on key cerebral suphydryl proteins - A novel component of its GPx-mimic antioxidant mechanism emerging from its thiol-modulated toxicology and pharmacology

however, results are inconsistent

Up to 10% of APAP undergoes phase I oxidation to a reactive intermediate, N-Acetyl-Para-Benzoquinone Imine (NAPQI), which is normally conjugated with glutathione to nontoxic cysteine and mercapturate metabolites [20]

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