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(2010) noted that MT-II may produce rapidly pigmenting nevi [10]

FIGURE 6 2.5 Skin fibrosis Hypertrophic scar is a prevalent yet inadequately resolved fibrotic dermatological condition, presenting as elevated, erythematous, indurated, and non-elastic plaques (Finnerty et al., 2016)

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Since isolated primary human islets cannot be cultured for extensive periods of time and exhibit donor-to-donor variability, most groups have historically relied on rodent models and cell lines to robustly understand the genetic and mechanistic components involved in the initiation and progression of T1D

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