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Srgio, S., Ramos, M

In summary, there remain three bottlenecks for clinical breakthroughs, as follows, the low bioavailability of natural products should be improved, the combined application of two or more compounds should be investigated for more prominent pharmacological effects and the evidence of clinical efficacy of other compounds requiring further confirmation

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Additionally, the deposition of laminin, a key component of the basement membrane crucial for vascular integrity, further underscored the vascular perturbations characteristic of EAE (Roscoe and Welsh 2009)