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In a randomized controlled trial, 120 women with episodic migraines were randomly assigned to receive either 300 mg B1, 80 mg B6, 2 mg folic acid, 500 mcg B12, a combination of all of these B vitamins at the aforementioned dosages, or placebo daily for 12 weeks

A comprehensive meta-analysis demonstrates that AS-IV significantly improves LVEF, reduces left ventricular end-diastolic pressure, downregulates myocardial creatine kinase and troponin expression, optimizes ST segment depression, and minimizes the MI area (Zheng et al., 2018)

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It catalyzes dietary choline to betaine