A substudy published in Nature Medicine enrolled 98 participants with MASLD for 48 weeks (Nature Medicine, 2024): At 12 mg, 93% of participants with fatty liver achieved normal liver fat levels
Research has focused on amylin receptor agonism (AMY1, AMY2, AMY3) and downstream effects on food intake, gastric emptying and energy homeostasis
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Severity and frequency both declined as patients' bodies adapted to the medication
Is the effect similar? Ultimately, the data show promise of another strategy for people struggling with alcohol use disorder and even the use of other addictive substances
