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These insights suggest that future investigations should prioritize tissue-specific mitochondrial analyses, including assessments of mtDNA heteroplasmy and functional studies in relevant tissues

Nitric oxide formed by nitrite reductase of Paracoccus denitrificans is sufficiently stable to inhibit cytochrome oxidase activity and is reduced by its reductase under aerobic conditions

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A landmark 2017 mouse study showed functional rejuvenation

This sequence of events was demonstrated in a double-blind, crossover design study performed with healthy man volunteers [86]