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A second cohort of mice including WT, RAMP1 KO, RAMP3 KO, and RAMP1/3 KO genotypes confirmed that both RAMP1 and RAMP3 are individually essential for a full cagrilintide-induced neuronal activation response

Additionally, GLP-1R agonists inhibit tau protein hyperphosphorylation, promote the release of brain-derived neurotrophic factor, and reduce neuroinflammatory responses by inhibiting microglial and astrocyte activation [55,56,57]

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