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10.1152/physiol.2024.39.S1.1778 31 CarlstrmM.LaiE

Exposing cerebral mitochondria to THC was reported to induce a ten-fold increase in free radical leak and increased H 2 O 2 production [40], while in epithelial cells, THC upregulated inflammation-related genes and downregulated antioxidant-related genes [34]

Peroxinitrite has long been considered to be a highly toxic metabolic by-product, damaging biomolecules including proteins, lipids, and DNA

In some embodiments, the percentage of active agent is varied between about 1% and about 95%, between about 5% and about 80%, between about 10% and about 60% or more of the weight or volume of the total pharmaceutical formulation

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