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Estriol-containing formulas (Biocosmetic Cream, Biocosmetic + SNAP-8, Methylene Blue Cream) are flagged for provider review in patients with hormone-sensitive cancer history and are a hard contraindication in pregnancy or breastfeeding

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For instance, meta-analysis on the peripheral blood levels of these components demonstrates that individuals with BD present lower peripheral blood levels of tryptophan, Kyn, KYNA, xanthurenic acid (a component derived from 3-HK), KYNA/Kyn and KYNA/QA ratio [229]