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As apixaban is excreted in the intestine by transporters, concomitant drugs or food substances that block these intestinal transporters may increase the blood levels of apixaban leading to potential bleeding risk

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SJS and TEN share the same pathophysiology and are classified into three categories according to severity of cutaneous lesion: lesion area less than 10% of the total body surface area (BSA) is defined as SJS

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Both agencies require robust evidence of safety, efficacy, and quality before granting a licence