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A limitation of this study is the investigation of mRNA expression of insulin signalling genes which are not always reflective of protein function and enzyme activity

As dermatologists, we must emphasize the importance of healthy, well-cared-for skin, regardless of tone, and discourage treatments that reinforce negative stereotypes surrounding skin color

Given that PAR2-G37I mutation has no impact on fasted ghrelin or postprandial GLP-1 levels, the mechanism by which TMPRSS2 regulates GLP-1 is likely independent of canonical PAR2 cleavage by TMPRSS2