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2 Hyperuricemia is associated with various risk factors, including a high-purine diet, alcohol consumption, medication usage, hypertension, hypothyroidism, and obesity

On the other hand, such solvation anomalies are not expected to persist across more than one functional group, hence solvent-to-solvent correlation for p K a values across functional groups is rather poor (Tables 4, 5, 6, 7, 8, 9)

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