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Proc Natl Acad Sci USA 103: 299304 Harding HP et al

Clinical studies confirm that chronic treatment with AOD9604 showed no adverse effect on insulin sensitivity, making it a metabolically selective approach to body composition optimization under medical supervision

In preclinical models that simulate stress-induced depression, supplementation with Ashwagandha has been shown to markedly reduce the release of cytokines, restore antioxidant defenses (e.g., glutathione, superoxide dismutase), and lower markers indicative of oxidative stress (82)

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Compounding is a long-standing practice in medicine