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SELECT trial demonstrated 20% MACE reduction in 17,604 patients -- the first anti-obesity drug with proven cardiovascular benefit

Efficacy and safety of once-weekly semaglutide 1.0 mg versus once-daily liraglutide 1.2 mg as add-on to 13 oral antidiabetic drugs in subjects with type 2 diabetes (SUSTAIN 10)

The reason: If you already have thinning bones (osteopenia or osteoporosis) or severe loss of muscle mass, losing weight can exacerbate those problems especially if you fail to build adequate aerobic and strength-training exercise into your regimen

FAQS ABOUT GLP-1 WEIGHT LOSS TREATMENT Individuals with a BMI that meets the criteria for medical weight management or those struggling with weight-related health concerns may be candidates

NG28 Type 2 diabetes in adults: visual summary Choosing medicines for first-line and further treatment