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Although these studies are published in indexed journals, independent replication by other research groups remains insufficient to draw definitive conclusions about therapeutic efficacy in humans

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30,32 A retrospective matched case-control study of 324 patients who underwent ACL reconstruction with meniscus repair (PRP vs control age: 91.6 11.2 vs 92.4 10.6) showed no significant difference in IKDC scores nor in the timing of return to activity nor postoperative complications among the intraoperative PRP injection group and the control group after 2 years 33 In addition, Bailey et al

ATP exposure stimulates glutathione efflux as a necessary switch for NLRP3 inflammasome activation

Someone with significant metabolic dysfunction may see dramatic improvements, while someone already close to their ideal body composition may notice more subtle changes