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Retatrutide produces the largest heart rate increase but also the most significant blood pressure reduction and the greatest weight loss
Remarkably, beneficial effects have been observed across this 100-fold range, suggesting a wide therapeutic window where smaller doses remain biologically active
Symptoms may include sharp pain in the upper right abdomen, fever or visible yellowing of the skin for some skin tones
A lower tirzepatide dose may produce comparable weight loss to a higher semaglutide dose due to the added GIP mechanism
Unlike the VLED, semaglutide did not appear to downregulate levels of satiety hormones such as PYY and amylin, and upregulated CCK levels
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