doi: 10.1111/j.1365-2125.1986.tb02901.x
The RMSF for Tyr-72, Asp-74, Trp-86, Gly-120, Gly-121, Tyr-124, Tyr-133, Glu-202, Ser-203, Trp-286, Phe-295, Phe-297, Tyr-337, Phe-338, Tyr-341, His-447, and Gly-448 were selected and ranked, resulting in 6 residues being chosen from each of the 9 simulations (Supplementary Table S17)
The 5mg dose aligns with the formulations used across clinical peptide practices and provides a conservative entry point for assessing individual tolerance
skip if near next dose
Funding This work was supported by Major Project of Science and Technology Department of Yunnan Province (202002AA100005 and 202102AE090027-2), Cassava Industrial Technology System of China (CARS-11-YNTY), Yunnan Province Ten Thousand Plan Industrial Technology Talents project (YNWR-CYJS-2020-010), and R&D and application of key technologies for specialty new functional and nutritional health foods (2019ZG00905)