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We remain open to adjusting our finalized policy for the MS-DRG relative weights through future rulemaking prior to the effective date if appropriate
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However, despite its intended benefits, Zepbound has become the center of controversy due to its severe side effects, particularly gastrointestinal issues
Next, macrophages produce TGF- and PDGF-B factors which cause activation and proliferation of the resident pancreatic fibroblasts with subsequent induction of their transformation into myofibroblast-like cells [40, 41]
The first head-to-head clinical trial (SURMOUNT-5, published in the New England Journal of Medicine in 2025) showed tirzepatide produced 20.2% average weight loss at 72 weeks compared to 13.7% for semaglutide approximately 47% greater relative weight loss
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