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As levels decline with age, replenishing GHK-Cu has become an attractive therapeutic strategy in regenerative medicine and dermatology

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Therefore, in principle any changes are reversible, and indeed, histone acetylation levels can be decreased and increased, respectively, by inhibiting acetyltransferases (Baell et al, 2018

Research in the Journal of Clinical Endocrinology & Metabolism has shown that sustained GH elevation even modest increases significantly impacts visceral fat reduction and lean mass preservation in adults with age-related GH decline (Rudman et al., 1990, NEJM )