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Abstract Background Oral semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1 RA), has been shown to reduce major adverse cardiovascular events (MACE) in high-risk individuals with type 2 diabetes in the SOUL trial

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Multiple manufacturers, including AstraZeneca, Eli Lilly, Sanofi, and Novo Nordisk, unilaterally restricted 340B contract pharmacy arrangements between 2020 and 2022, citing what they characterized as diversion and duplicate discounts enabled by the PBM-contract pharmacy relationship