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pylori ferritins, allowing us to introduce single cysteine residues at defined positions for site-specific conjugation without the need to remove native cysteines

Several of the conotoxins contain two to five Gla residues

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6 Conclusion This review methodically substantiates the theoretical value of redefining diabetes as an immunometabolic disorder. This framework challenges traditional perspectives by addressing the fundamental mechanisms of immune-metabolic cross-regulation, thereby providing a unified pathophysiological explanation for the high susceptibility to infection, severe disease progression, and poor treatment outcomes observed in diabetic patients