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For diabetes management, an estimated 35 million adults qualified based on self-reported diabetes diagnoses, elevated HbA1c levels, or existing use of diabetes treatments

Losing muscle can lead to a slower metabolism, poor posture, reduced strength, decreased bone density, and an increased risk of weight regain after stopping the medication

The Centers for Disease Control and Prevention (CDC) ranks obesity and being overweight as common risk factors for COVID deaths, precisely because general unhealthiness causes underlying conditions, such as hypertension, which can make it harder for that person's immune system to fight a novel threat

Additionally, while the net effect on the heart is positive, the medication can cause a slight increase in resting heart rate