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It is widely known that the vagus nerve plays an important role in nausea, vomiting, and pain.120 Some of the vagal nerve branches are situated in the external ear and directly project from there to the brainstem, together with other cranial nerves.121 Auricular stimulation with transcutaneous electrical nerve stimulation is efficacious in pediatric patients with gut-brain axis gastrointestinal disorders and is currently approved by the US Food and Drug Administration for the treatment of irritable bowel syndrome in children

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Estradiol and progesterone alter the metabolites contained in EVs

Due to the low molecular weight of TB-500, it is extremely mobile

Lipid-protein interactions in OMM promote autophagosome recruitment and expansion and induce mitophagy