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However, using large data bases, studies have suggested that DPP-4 inhibitors have favorable effects on renal function and decrease the development of end stage renal disease (274-276)

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Rong H, Xie XH, Zhao J, Lai WT, Wang MB, Xu D, et al

Feasibility of Catalpol intranasal administration and its protective effect on Acute cerebral ischemia in rats via anti-oxidative and anti-apoptotic mechanisms

The Look AHEAD trial observed a 5% reduction in body weight was associated with sustained improvements in key cardiovascular risk factors such as blood pressure and lipid profile [7]