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NF-B Pathway LPO products such as 4-HNE have been shown to interfere with NF-B activation at the level of IB kinase (IKK) which is an important molecule phosphory-lating IB for its degradation [14, 128]

Another enzyme then breaks the toxic acetaldehyde down even further into acetate, which is non-toxic

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2012), our observation that APAP decreased GJ abundance suggested that hepatocytes mount a defense against the spread of oxidative stress molecules within liver tissue during the early stages of APAP exposure by reducing the expression of Cx32 (and consequently GJs)