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Lightheadedness: Uncommon, usually dose-related and resolves with adjustment

Studies looking at NR doses up to 2,000mg per day and NMN doses up to 1,200mg per day found no differences in adverse effects between intervention and placebo groups.31 4 In studies of higher doses that produced adverse effects, typical reactions included:32 Headache Dry mouth GI upset Muscle cramps or spasms As with many forms of vitamin B, NR can cause some flushing, and both NR and NMN can cause digestive upset

A confident manufacturer will stand behind their product with a substantial guarantee, typically 60 days or more

Moreover, this met-analysis was a bit fruity in that it compared a lot of apples with oranges, meaning that it combined trials that really sued berberine for different purposes