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The treatment groups outperformed placebo by 5.5 (Group A) to 7.4 (Group B), providing clear evidence that the improvement was caused by the active ingredients, not the placebo effect

For example, melatonin, -endorphin, and phenylpropanolamine all lower seizure thresholds within a day

Am J Clin Nutr 2011;94:348S-58S

Animal studies in diet-induced obese rats show tesofensine treatment produces improvements in metabolic status including increased insulin sensitivity, reductions in plasma lipid levels, and enhanced glucose homeostasis

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