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As per WHO, the population of people aged 60 years and older worldwide is expected to double, reaching 2.1 billion by 2050

Calcium stimulates release of insulin from an insulinoma or hyperplastic beta cells

86 In 2014, the drug empagliflozin (EMPA) was approved for the treatment of T2DM

Importantly, analogous behavior has been reported beyond titanium (e.g., zirconia), suggesting that the core mechanism is not metal-specific but instead linked to carbon pellicle removal and restoration of hydrophilicity across clinically relevant biomaterials [102]