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A 2021 review confirmed no clinical trials targeting NNMT had been reported [5], and MOTS-c likewise has no large human efficacy trial proving it works as a fat-loss therapy

BPC-157 has a short plasma half-life (on the order of minutes intravenously ) but its systemic effect exceeds pharmacokinetics, the mechanism acts via signalling cascades and transcription factors

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A 2025 pilot study tested IV BPC-157 up to 20 mg in 2 healthy adults for safety only, finding it well tolerated but conducting no efficacy testing