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However, it was not recognized at the time that evidence for the protein binding hypothesis was obtained in animals on a normal diet whereas the LPO hypothesis was derived from animals fed a vitamin E-deficient diet high in polyunsaturated fatty acids (PUFAs), i.e., in animals highly susceptibility to LPO [61]

Until 2015, a common limitation of the identified GIP receptor antagonists was the absence of human data, raising concerns about their potential clinical application

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Early treatment challenges sometimes cause patients to stop prematurely because they mistake slow initial progress for treatment failure

in saline solution)