Despite a lack of direct evidence showing that FOXO4-DRI can eliminate senescent Leydig cells in aged mice, we observed that FOXO4-DRI treatment alleviates the testicular senescence phenotype, improves the testicular microenvironment, and increases serum testosterone levels, all of which could contribute to the therapeutic effects of FOXO4-DRI
Kim Y, Cho JY, Oh SW, Kang M, Lee SE, Jung E
This facilitates cellular uptake and accumulation in organelles like mitochondria, where its positive charge drives electrostatic localization in the mitochondrial matrix (Nedu et al
In the SR4-treated group, hepatocellular vacuolation was minimally observed and a notable improvement in lipid accumulation with a marked reduction in the number and size of lipid droplets was detected in the liver of these animals